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KMID : 0385019990150020201
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 2 p.201 ~ p.206
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Effective Eradication Policy of Pinworm(Oxyurids) in Laboratory Animal Facility
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김길수/Kim, Kil Soo
한진수/권명상/김진희/Han, Jin Soo/Kwon, Myung Sang/Kim, Heui Jin
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Abstract
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Oxyurids (pinworms), a Nematodes, are common parasites of laboratory animal facilities in the world, and occur commonly in the cecum and colon of the rodents. Their infection in rodents induces weight gain, immunomodulation, growth and breeding rate retardation, and even death when predisposed to large worm burdens. It is difficult to control pinworms because even though the anthelminthics can easily eliminate adult worms, the treated animals are infected again by egg intake.
Thin study was designed to establish an effective eradication plan in the animal facility, and performed experiments to be followed: comparing the eradication effect of abamectin and ivermectin spray against pinworm (Syphacia maris) in rata, and investigating the preventive capacity of filter-cap against pinworm infection and reinfection. These experiments were evaluated by the perianal cellophane tape teat for detecting pinworm eggs and the macroscopic detection of adult worm in the cecum and colon. The experimental groups were cared by efficient management protocol and divided in (+) control (pinworm positive), ivermectin (10X dilution), absmectin I (10X) and abamectin B (20X).
The pinworm eggs of the treated groups were completely eradicated after first abamectin and invermectin spray treatment. In addition, abamectin showed equal potency even half concentration of ivermectin. In the result of the autopsy, none of adult worms was detected in cecum and colon of the treated groups. The filter-cap also prevented pinworm infection form the (+) control to sentinels.
It is concluded that the sbamectin spray is effective and easy method for pinworm eradication, and the filter-cap and proper management protocol is essential for pinworm control in the animal facility.
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